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Click Here: Peer-reviewed Articles
  1. R.S. Beard Jr., X. Yang, C.G. Yang, J.A. Elliott, J.E. Meegan, J.J. Reynolds, C.D. Pivetti, D.A. Mitchell, M.H. Wu, R.J. Deschenes, S.Y. Yuan. Palmitoyl Acyltransferase DHHC21 Mediates Endothelial Dysfunction in Systemic Inflammatory Response Syndrome. Nature Comm. 2016 Sep 22;7:12823.
  1. R.J. Haines, R.S. Beard Jr., R. A. Eitnier, L. Chen, M.H. Wu. TNFα/IFNγ Mediated Intestinal Epithelial Barrier Dysfunction Is Attenuated by MicroRNA-93 Downregulation of PTK6 in Mouse Colonic Epithelial Cells. PLoS One. 2016 Apr 27;11(4):e0154351.
  1. R.J. Haines, R.S. Beard Jr., L. Chen, R. A. Eitnier, M.H. Wu. IL-1β activation of non-muscle myosin light chain kinase mediates β-catenin driven downregulation of claudin-3 in Caco2 cells. Digest Dis Sci. In press.
  1. H.M. Bass, R.S. Beard Jr., B.J. Cha, S.Y. Yuan, P.R. Nelson. Thrombomodulin induces a quiescent phenotype and inhibits migration in vascular smooth muscle cells in vitro. Ann Vasc Surg. 2016 Jan;30:149-56.
  1. R.J. Haines, R.S. Beard Jr., M.H. Wu. Protein tyrosine kinase 6 mediates TNFα-induced endothelial barrier dysfunction. Biochem Biophys Res Commun. 456(1):190-6, 2015, 2015.
  1. V. Chatterjee, R.S.Beard Jr., J.J. Reynolds, R.J. Haines, M. Guo, M. Rubin, J. Guido, M.H. Wu, S.Y. Yuan MicroRNA-147b regulates vascular endothelial barrier function by targeting ADAM15 expression. PLoS One. 9(10):e110286, 2014. PMID: 25333931
  1. R.S. Beard Jr., R.J. Haines, K.Y. Wu, J.J. Reynolds, S.M. Davis, J.E. Elliott, M.H. Wu, N.L. Malinin, V. Chatterjee, B.J. Cha, S.Y. Yuan. Non-muscle myosin light chain kinase is required for β-cat/FoxO1-dependent downregulation of claudin-5 in interleukin-1β-mediated brain endothelial cell barrier dysfunction. J Cell Sci. 127(Pt 8):1840-53, 2014. PMID: 24522189
  1. B.C. Rhodehouse, J.N. Mayo, R.S. Beard Jr., C.H. Chen, S.E. Bearden. Opening of the blood-brain barrier before cerebral pathology in mild hyperhomocysteinemia. PLoS One. 8(5):e63951, 2013. PMID: 23696861
  1. C. Sun, R.S. Beard Jr., D.L. Mclean, R.R. Rigor, T. Konia, M.H. Wu, S.Y. Yuan. ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice. Am J Physiol Lung C. 304(3):L135-42. Feb 2013. PMID: 23161886
  1. C.H. Chen, R.S. Beard Jr., S.E. Bearden. Homocysteine impairs endothelial wound healing by activating metabotropic glutamate receptor 5. Microcirculation. 19(4):285-95, 2012. PMID: 22221504
  1. R.R. Rigor, R.S. Beard Jr., O.P. Litovka, S.Y. Yuan. Interleukin-1β-induced barrier dysfunction is signaled through PKC-θ in human brain microvascular endothelium. Am J Physiol-Cell Ph. 302(10):C1513-22, 2012. PMID: 22403784
  1. R.S. Beard Jr., J.J. Reynolds, S.E. Bearden. Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteine. Vascul Pharmacol. 56(3-4):159-67, 2012. PMID: 22285407
  1. J.N. Mayo*, R.S. Beard Jr.*, O.P. Tulin, C. Chen, M. Erikson, N. Ercal, W.A. Banks, S.E. Bearden. Nitrative stress in cerebral endothelium is mediated by mGluR5 in hyperhomocysteinemia, J Cereb Blood Flow Metab. 32(5):825-34, 2012. PMID: 22186670 * Equal authorship.
  1. R.S. Beard Jr., J.J. Reynolds, S.E. Bearden. Hyperhomocysteinemia increases permeability of the blood-brain barrier by NMDA receptor-dependent regulation of adherens and tight junctions. Blood. 118(7):2007-14, 2011. PMID: 21705496
  1. R.S. Beard Jr., S.E. Bearden. Vascular complications of cystathionine β-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research. Am J Physiol-Heart C. Review. 300: H13-H26, 2011. PMID: 20971760
  1. S.E. Bearden, R.S. Beard Jr., J.C. Pfau. Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress. Am J Physiol-Heart C. 299: H1568-H1576, 2010. PMID: 20817827

Click Here: Published Meeting Abstracts
  1. R.J. Haines, R.S. Beard Jr., M.W. Wu. PTK6 Mediates TNFα Driven Intestinal Epithelial Barrier Dysfunction by Activation of Focal Adhesion Kinase. Poster presentation delivered at Digestive Disease Week 2016, San Diego, CA. Gastroenterology. 150(4):S961.
  1. J.W. Sherwood, R.S. Beard Jr., C.S. Landon, J.B. Dean. Chronic Exposure to Elevated Ambient CO2 Influences the Orexinergic System in the Lateral Hypothalamus and Dorsocaudal Medulla. Poster presentation delivered at the Experimental Biology Conference 2016, San Diego, CA. FASEB J. 30(772.9).
  1. R.S. Beard Jr., R.J. Haines, J.W. Overstreet, J.E. Meegan, M.H. Wu, S.Y. Yuan. Selective Activation of the PI3K/Akt Pathway With the Insulin Mimetic Demethylasterriquinone B1 Reverses Neuroinflammatory-Mediated Blood-Brain Barrier Dysfunction in Mice. Poster presentation delivered at the American Heart Association-Scientific Sessions 2014, Chicago, IL. Circulation. 130(A20574-A20574).
  1. C. Palmiotti, R.S. Beard Jr., A. Conway, F. Sinatra, S.Y. Yuan, S. Sundaram, A.K. Achyuta. Inflammatory Cell Trafficking Dynamics Across the Blood-Brain Barrier on a Novel Fluidic Platform. 2014 Biomedical Engineering Society Annual Meeting, San Antonio, TX.
  1. R.S. Beard Jr., K.Y. Wu, J.J. Reynolds, S.M. Davis, R.J. Haines, J.A. Elliott, M.H. Wu, S.Y. Yuan. Interleukin-1β-induced BBB dysfunction involves decreased claudin-5 protein expression and is dependent on non-muscle myosin light chain kinase. Poster presentation delivered at the Experimental Biology Conference 2013, Boston, MA. FASEB J. 27(896.10).
  1. R.S. Beard Jr., J.N. Henry, T. Otamis-Price, N. Ercal, W.A. Banks, S.E. Bearden. Homocysteine disrupts NO metabolism in brain microvascular endothelial cells by an mGluR5-dependent mechanism. Poster presentation delivered at the Experimental Biology Conference 2011, Washington D.C. FASEB J. 25(820.11).
  1. R. Wu, R.S. Beard Jr., X. Cui, J.A. Elliot, J. Guido, M.H. Wu, S.Y. Yuan. CD44-mediated Src signaling in endothelial barrier dysfunction. Experimental Biology Conference 2013, Boston, MA. FASEB J. 27(896.7).
  1. B.C. Rhodehouse, J.N. Mayo, R.S. Beard Jr., C.H. Chen, S.E. Bearden. Blood-brain barrier leak precedes brain histopathology and cognitive impairment in mild hyperhomocysteinemia. Experimental Biology Conference 2013, Boston, MA. FASEB J. 27(709.11).
  1. C.H. Chen, R.S. Beard Jr., S.E. Bearden. Homocysteine activates mGluR5- and PKC- dependent Cx43 phosphorylation at S368 and impairs proliferation of brain microvascular endothelial cells. Experimental Biology Conference 2011, Washington D.C. FASEB J. 25(636.1).
  1. R.S. Beard Jr., S. E. Bearden. Homocysteine increases cerebral EC barrier permeability through the NMDA receptor in vitro and in vivo. Oral presentation delivered at the American Heart Association-Scientific Sessions 2010, Chicago, IL. Circulation. 122(16456).
  1. R.S. Beard Jr., S.E. Bearden. Homocysteine Induces Phosphorylation of Y731 on VE-cadherin by Activating a Metabotropic-to-Ionotropic Glutamate Receptor Cascade. Poster presentation delivered at the American Heart Association-Scientific Sessions 2010, Chicago, IL. Circulation. 210(A16167).
  1. C.H. Chen, R.S. Beard Jr., A.C. Straub, K.H. Heberlein, B.H. Isakson, S.E. Bearden. Homocysteine modulates the density and composition of myoendothelial junctions. American Heart Association-Scientific Sessions 2010, Chicago, IL. Circulation. 122(21).